Ledisa Patch Review: 90 Days, 10.8 Pounds, and an Honest Verdict

Why a 62-year-old woman in Ohio wrote a 2,500-word review of a botanical patch

My name is Linda Halberg. I taught high-school English in the Columbus suburbs for twenty-eight years before I retired in 2021. I am 5'5". In 2022, three months after my last menstrual cycle, I weighed myself for the first time in a decade and saw a number that did not match the body I thought I lived in. By the end of 2023, I had gained nineteen pounds. The diet that used to work — half-portions for two weeks, walk a little more — suddenly did not. My endocrinologist used the phrase "metabolic recalibration of menopause" and prescribed Wegovy.

Wegovy, briefly, was a miracle. Two weeks in, I forgot to think about food for an entire afternoon. Then the nausea started, and it did not stop. By week six I had lost twelve pounds and could not eat anything more textured than yogurt. My insurance company also informed me that my coverage was a one-year trial and would not renew. I came off it in March 2024 and put eight of the twelve pounds back on by July. I tried Mounjaro through a compounding pharmacy for six weeks in late 2024. Same nausea, plus a constant low-grade headache. I quit.

I bought Ledisa in February 2025 because my younger sister — also post-menopausal, also a Wegovy failure — said her appetite went quiet on it and she had not gained any weight back. She is not a person who falls for things. I treated it as an experiment and decided I would write down everything for ninety days whether it worked or not.

This review is what came out of those ninety days. I have no financial relationship with the brand and was not given the product. I paid full price for the three-month bundle (subscription, which I will cover below — there is a thing to know there). The site you are on has affiliate links, which means I may earn a small commission if you click through and buy. The author of those links is also the author of this review, and you can take that for whatever it is worth.

What the Ledisa patch actually is

Ledisa is a transdermal adhesive patch the size of a quarter. The disc itself is teal-blue with a white four-point star and the word "Ledisa" printed across the center. You peel a paper backing off and stick it to clean, dry skin somewhere with thin tissue: inner upper arm, inner forearm, lower abdomen, upper thigh. You leave it on for 24 hours and replace it the next morning, rotating to a fresh site.

The patch contains five botanical ingredients suspended in a hypoallergenic adhesive matrix. In rough order of dose:

• Berberine — an alkaloid from the barberry plant, the most studied ingredient in the formula. Oral berberine has roughly two decades of metabolic research behind it, including comparisons to metformin in human trials. See the PubMed entry for Yin et al. (2012), a clinical comparison of berberine and metformin in patients with type 2 diabetes.
• Cinnamon bark extract — included for its effect on post-meal blood sugar. A 2019 meta-analysis in the journal Clinical Nutrition found modest effects on fasting glucose at doses higher than what most patches deliver.
• Green tea extract (EGCG) — modest effects on resting metabolic rate in some studies. A 2010 systematic review at the NIH summarizes the catechin literature.
• Apple cider vinegar — a small 2024 trial in BMJ Nutrition, Prevention & Health reported a measurable effect on weight in young adults with obesity. The effect size was real but the sample was small and the population was not post-menopausal women.
• Chromium picolinate — long-standing inclusion in metabolic supplements; effects on cravings are inconsistent across studies.

This is a botanical stack. It is not pharmacology. The realistic mechanism, if it works, is a small downward nudge on appetite and post-meal glucose spikes — not a knockout dose of any one thing. If you are coming off Wegovy and expecting Wegovy-grade appetite suppression, you will be disappointed. If you are coming from nothing and want to see whether a small, daily, behavioral support tool helps, that is the right frame.

The 90-day log, condensed

Week 1: Nothing yet, and a small skin reaction

I started on a Monday morning, inner left forearm, and made a calendar reminder to rotate every day. On day three I noticed mild redness — a quarter-sized pink ring after I peeled the patch off. It faded by evening. On day four I put the next patch on the inside of my right upper arm and the redness was gone the next morning. I learned to keep the patch off the same square inch of skin twice in a row.

No appetite change in week one. I weighed in Sunday morning, same scale, same time, same bare feet: down 0.4 pounds, which is within the range of water weight variation. I logged it and moved on. I had decided in advance not to weigh more than once a week, because I know myself and I know what happens when I weigh every day.

Week 2: The 3pm snack attack quiets down

The clearest first change for me was around day ten. I always have a 3pm hunger spike — it used to be cheese and crackers, then a small handful of almonds when I was being good, then cheese and crackers again. On day eleven I noticed it was 4pm and I had not eaten anything since lunch. I was not hungry. I was not suppressing it. The thought of food just had not arrived. The same thing happened on day twelve.

Week 2 weigh-in: down 1.6 pounds from start. Still in the noise, technically, but in combination with the snack-attack effect I started to believe something was actually happening.

Weeks 3 to 6: The slow burn

This is the boring middle. I did not see dramatic changes. I did notice that evenings were quieter — the after-dinner urge to graze, which my husband Tom and I had built a whole television-watching ritual around, just stopped showing up some nights. I would sit down with my book and at 10pm realize I had not gotten up to look in the refrigerator. By week four this was a pattern, not a one-off.

By the end of week six I was down 5.4 pounds. The scale was moving in the right direction at roughly a pound a week, which is the sustainable rate every reasonable source I have ever read recommends. I had also, without consciously trying, increased my walking — I am retired, I have time, and when my appetite is calmer my motivation is better. My Apple Watch said I was averaging 7,800 steps a day in week six versus 5,200 in week one. That is a confounder. I am not going to pretend it is not.

Weeks 7 to 12: Plateau, and a second skin reaction

Weeks seven and eight were a plateau. I bounced between 181 and 182 for thirteen days. This is normal. I have been on enough weight-loss attempts to know that bodies do not produce monotonic graphs. I held the line, did not increase the patch dose, did not start anything new, and kept walking.

On day fifty-six I got my second skin reaction — a more itchy one, on the inside of my right thigh, where I had not used the patch in two weeks but where I had also been wearing thicker leggings during a cold snap. The redness lasted about four days. I rotated back to my arms exclusively for the next week and it cleared up. I did not take a break from the patch itself. Other reviewers I have read have, and that is reasonable; I just did not want to interrupt the experiment.

Week 10: down 8.1 pounds. Week 11: down 9.4 pounds. Week 12: 10.8 pounds, final weigh-in 176.2.

If you want to see the product itself, you can see the current price and the auto-renewal terms on the official site.

The thing about the subscription

I want to flag this because it is the single most common complaint I see when I read other reviews and Reddit threads. The default purchase on tryledisa.com is a subscription. You can buy a single month, but the bundles — three months, six months — are deeply discounted and the brand defaults you into auto-renewal at the bundle interval. If you buy the three-month bundle and do not cancel before day 90, your card is charged again for another three months.

I knew this going in because my sister warned me. I went into my account on day 60 and turned auto-renewal off. The cancellation flow worked in two clicks. But I have read enough complaints from people who did not know about the auto-renewal — or knew, and forgot — that I think this deserves to be flagged on every review of this product. My separate page on the Ledisa refund policy walks through the cancellation flow in detail.

This is not a unique pattern. Most direct-to-consumer supplement brands do this now. It is still worth being aware of.

Side effects: the honest list

• Mild skin redness at the patch site, twice in 90 days, both times resolving in a few days with site rotation. No blistering, no peeling, no lasting mark.
• A faint metallic taste in the back of my mouth in week one. It went away by day five. I have no idea if it was the patch or coincidence.
• Nothing else. No nausea, no headaches, no dizziness, no sleep disruption. Compared to Wegovy and Mounjaro, this was a non-event.

If you have a history of contact dermatitis or adhesive allergy, this product is not for you. If you are on any medication that affects blood sugar (metformin, insulin, sulfonylureas), blood pressure, or clotting, the berberine in this patch can interact and you need to talk to your prescriber before starting. The NIH National Center for Complementary and Integrative Health has a short, sensible primer on berberine interactions worth reading first.

What did not change, and what I did not measure

I want to be specific about what this patch did not do for me, because over-promising is how products like this lose trust:

• It did not change my energy levels. I do not feel "more alive." I just stopped grazing at night.
• It did not change my sleep. My sleep is what it has always been since menopause — fine, occasionally interrupted, not different.
• It did not change my mood. If anything is doing that, it is the walking.
• I did not measure waist or hip circumference, body fat, A1C, fasting glucose, or any other clinical marker. I have an appointment with my GP in July and I will ask for an A1C draw then. If it changes meaningfully I will update this page.

Who I think the Ledisa patch is and is not for

It is probably for:

• Women past 50 who have tried a GLP-1 injection drug and either could not tolerate the side effects or lost insurance coverage.
• Women who do not qualify for a prescription GLP-1 (the eligibility is narrower than the marketing implies) but want a small, daily, low-effort tool for appetite control.
• People who are already willing to walk daily and eat reasonably and want something that gently reinforces those habits rather than replaces them.

It is probably not for:

• People expecting Wegovy-grade appetite suppression. This is not that.
• People with sensitive skin or adhesive allergies.
• People who want a single product to do all the work. Nothing in this category does that, prescription or otherwise.
• Anyone unwilling to read the auto-renewal terms before buying.

The bottom line, 90 days in

I have my next three-month supply on the shelf — I bought a second bundle at the end of week ten because the price drops on the longer commitment and because I was already seeing the effect. I do not know what I will weigh at day 180. I do know that I have not had a serious 3pm snack attack in eight weeks, and I cannot remember the last time I went to the kitchen after dinner to find something to eat. If those two things hold, I will keep using it.

This is one woman's experience. I cannot tell you what you will lose, or whether you will lose anything. I can tell you the patch did what it said it would do for me, at a pace that was sustainable, with side effects that were manageable, and at a price that was a fraction of what I paid for two months of Wegovy out-of-pocket. For a post-menopausal woman in the same boat I was in two years ago, that is a real thing.

If you want to see the current pricing, the ingredient label, and the refund terms in one place, you can view the official Ledisa product page here. I will keep updating this review at the bottom of the page as my own log continues.

Related reading on this site: how the Ledisa patch compares to Wegovy, an ingredient-by-ingredient research breakdown, a full side-effect catalog with medication interaction notes, and the harder question of whether this patch actually works at all.